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| ORIGINAL ARTICLE |
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| Year : 2013 |
Volume
: 6 | Issue : 1 | Page
: 31-38 |
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Effect of yoga exercise therapy on oxidative stress indicators with end-stage renal disease on hemodialysis
Lorenzo Gordon1, Donovan A McGrowder2, Yeiny T Pena3, Elsa Cabrera4, Marilyn B Lawrence-Wright5
1 Kingston Public Hospital, North Street, Jamaica
2 Department of Pathology, Faculty of Medical Sciences, University of the West Indies, Mona, Jamaica
3 Department of Medicine, May Pen Hospital, Clarendon, Jamaica
4 Hermanos Ameijeiras Hospital, Havana, Cuba
5 Department of Medicine, University of the West Indies, Mona, Kingston 7, Jamaica
Correspondence Address:
Lorenzo Gordon
Department of Medicine, Kingston Public Hospital, North Street, Kingston
Jamaica
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-6131.105944
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Background: Oxidative stress promotes endothelial dysfunction and atherosclerosis in chronic renal disease.
Objectives: This study investigated the impact of Hatha yoga on oxidative stress indicators and oxidant status, in patients with end-stage renal disease (ESRD) on hemodialysis.
Design: This prospective randomized study consisted of 33 ESRD patients in the Hatha yoga exercise group who were matched with 35 ESRD patients in the control group.
Outcome Measures: The oxidative stress indicators (malondialdehyde - MDA, protein oxidation - POX, phospholipase A2 - PLA2 activity) and the oxidative status (superoxide dismutase (SOD) and catalase activities) were determined in the blood samples taken at the pre-hemodialysis treatment, at baseline (0 months) and after four months.
Results: In patients in the Hatha yoga exercise group, lipid peroxidation, as indicated by MDA decreased by 4.0% after four months (P = 0.096). There was also a significant reduction in the activity of PLA from 2.68 ± 0.02 IU / L to 2.34 IU / L (− 12.7%; P = 0.010) and POX from 2.28 ± 0.02 nmol / mg to 2.22 ± 0.01 nmol / mg (− 22.6%; P = 0.0001). The activity of SOD significantly increased from 12.91 ± 0.17 U / L to 13.54 ± 0.15 U / L (4.65%; P = 0.0001) and catalase from 79.83 ± 0.63 U / L to 80.54 ± 0.80 U / L (0.90%; P = 0.0001). There was a significant correlation between the pre-hemodialysis oxidative stress parameters at the zero month and after four months for the activities of PLA (r = 0.440), catalase (r = 0.872), and SOD (r = 0.775).
Conclusions: These findings suggest that the Hatha yoga exercise has therapeutic, preventative, and protective effects in ESRD subjects, by decreasing oxidative stress. |
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